Surficial Geologic Map of the Constantine 7.5-Minute Quadrangle, Kentucky

The Constantine 7.5-minute quadrangle is located west of Elizabethtown along the boundary of Hardin and Breckinridge Counties. The quadrangle lies along the northern section of the Dripping Springs Escarpment, which separates the Mammoth Cave Plateau and Pennyroyal regions of the Mississippian Sinkhole Plain physiographic province (McFarlan, 1943). Topography is mostly characterized by high-elevation plateaus, ridges, and knobs of the Mammoth Cave Plateau (up to 919 ft), which have been intensely dissected by the Rough River and its tributaries (down to 516 ft). A small area of the Pennyroyal extends into the eastern part of the quadrangle, which is marked by a relatively low-relief, low-elevation sinkhole plain. Sable (1964) mapped the bedrock geology of the quadrangle, which was later digitized by Conley (2002). Bedrock throughout the quadrangle is mapped as Upper Mississippian. A series of northeast-trending faults through the southeastern half of the quadrangle (splays from the Rough Creek Fault System) have created a series of horst and graben structures that control bedrock exposure and stream incision. The oldest bedrock lithologic unit mapped is the Ste. Genevieve Limestone, which is overlain by the Paoli Limestone; both are exposed in the Pennyroyal region in the eastern part of the quadrangle and northwest of the fault system. The Mooretown Formation and Beaver Bend Limestone are mostly exposed along steep slopes above the Paoli Limestone; a large area of Mooretown Formation is locally exposed in a broad plain situated northwest of the fault system in the center of the quadrangle. The Sample Sandstone overlies the Beaver Bend Limestone and covers the largest portion of plateaus and ridgetops in the area, mostly northwest of the fault system. The Reelsville Limestone and Golconda Formation overlie the Sample Sandstone and are exposed in isolated knobs and ridges northwest of the fault system, and extensively in the southeastern section of the quadrangle, where they are overlain by the Hardinsburg Sandstone, the youngest unit mapped in the Constantine quadrangle.https://uknowledge.uky.edu/kgs_cr/1002/thumbnail.jp

Surficial Geologic Map of the Millerstown 7.5-Minute Quadrangle, Kentucky

The Millerstown 7.5-minute quadrangle is located south of Louisville and southwest of Elizabethtown along the boundaries between Hardin, Grayson, and Hart Counties and within the Mississippian Plateau physiographic region (McDowell, 1986). Topography is characterized by the low relief Pennyroyal plain that sits at altitudes below about 650 ft above sea level, the low relief Mammoth Cave plateau at altitudes above about 650 ft, and steep slopes of and isolated knobs of the incised Dripping Springs escarpment that separates the two plains. Moore (1965) mapped the bedrock geology of the quadrangle, which was later digitized by Johnson (2006). Mississippian bedrock and local areas of Pennsylvanian bedrock are exposed throughout most of the quadrangle, all, of which, are cut by several vertical faults. The Ste. Genevieve Limestone is the oldest lithology and underlies the Pennyroyal region in the northeast and southwest corners of the quadrangle, and locally along the Nolin River. The Beaver Bend Limestone, Mooretown Formation, Paoli Limestone, Sample Sandstone, and Reelsville Limestone stratigraphic sequence underlie most of the remaining Pennyroyal plain and several steep slopes of the Dripping Springs escarpment. The Beech Creek Limestone, Big Clifty Sandstone, and Haney Limestone Members of the Golconda Formation are exposed along the Dripping Springs escarpment the edges of the Mammoth Cave plateau region. Most of the Mammoth Cave plateau is underlain by the Hardinsburg Limestone, and, locally in the southwest corner of the quadrangle, the Glen Dean Limestone, Leitchfield Formation, and Pennsylvanian Caseyville Formation. Previously mapped surficial deposits include minor areas of alluvium in tributaries across the Millerstown quadrangle (Moore, 1964)

Surficial Geologic Map of the Summit 7.5-Minute Quadrangle, Kentucky

The Summit 7.5-minute quadrangle is located south of Louisville and west of Elizabethtown along the boundary between Hardin and Grayson Counties and within the Mississippian Plateau physiographic region (McDowell, 1986). Topography is characterized by the low relief Pennyroyal region that sits at elevations between 560 to 650 ft above sea level, the low relief Mammoth Cave plateau at elevations between 750 to 900 ft, and the steep Dripping Springs escarpment that separates the two plains. Moore (1964) mapped the bedrock geology of the quadrangle, which was later digitized by Conley (2002). Mississippian bedrock is exposed throughout the quadrangle and is cut by several vertical faults. The St. Louis Limestone and overlying Ste. Genevieve Limestone underlie the Pennyroyal region and are the oldest bedrock units in the quadrangle. The Beaver Bend and Paoli Limestones, Sample Sandstone, Reelsville Limestone, and Beech Creek Limestone Member of the Golconda Formation are exposed along the Dripping Springs escarpment. The Mammoth Cave plateau region is underlain by the Big Clifty Sandstone and, locally, Haney Limestone Members of the Golconda Formation east of the Summit Fault, and Hardinsburg Sandstone west of the fault. Previously mapped surficial deposits include minor areas of alluvium in tributaries across the Summit quadrangle, and areas of “slumped sandstone” (colluvium) in the Pennyroyal region (Moore, 1964)

Surficial Geologic Map of the Upton 7.5-Minute Quadrangle, Kentucky

The Upton 7.5-minute quadrangle is located south of Elizabethtown along the boundaries between Hardin, Hart, and Larue Counties and within the Mississippian Plateau physiographic region (McDowell, 1986). Topography is characterized by the low relief Pennyroyal plain that sits at altitudes below about 750 ft above sea level, the ridges, spurs, and isolated knobs of the intensely dissected Dripping Springs escarpment; the low relief cap of the escarpment landforms is part of the Mammoth Cave plateau region. Moore (1972) mapped the bedrock geology of the quadrangle, which was later digitized by Toth (2006). Mississippian bedrock is exposed throughout most of the quadrangle and is cut by several northwest-southeast trending vertical faults. The Ste. Genevieve Limestone is the oldest lithology and underlies most of the Pennyroyal region. The Beaver Bend Limestone and Paoli Limestone, Sample Sandstone, and Reelsville Limestone stratigraphic sequence underlie the remaining areas of the Pennyroyal, as well as the lower slopes of the Dripping Spring escarpment. The Beech Creek Limestone, Big Clifty Sandstone, and Haney Limestone Members of the Golconda Formation are exposed along the upper slopes of the Dripping Springs escarpment the upper plains of the Mammoth Cave plateau. The Upper Mississippian Hardinsburg Limestone is exposed on the highest ridges of the Dripping Springs, and the Pennsylvanian Caseyville Formation is locally exposed around the highest peak in the southern part of the Upton quadrangle. Previously mapped surficial deposits include minor areas of alluvium in major tributaries, and “slumped” areas across the quadrangle (Moore, 1972)

The global impact of Aspergillus infection on COPD

From Springer Nature via Jisc Publications RouterHistory: received 2020-07-15, registration 2020-08-05, accepted 2020-08-05, pub-electronic 2020-09-11, online 2020-09-11, collection 2020-12Publication status: PublishedFunder: Manchester Biomedical Research Centre; doi: http://dx.doi.org/10.13039/100014653Abstract: Background: Advanced chronic obstructive pulmonary disease (COPD) often leads to hospitalisation and invasive aspergillosis (IA) is a serious complication. Aspergillus sensitisation may worsen symptoms in COPD. Methods: We identified published papers between January 2000 and May 2019 with > 50 subjects and GOLD criteria for grade II, III or IV (FEV1/FVC 0.05). Conclusions: The prevalence of COPD is much higher than previously estimated. Overall COPD mortality may be higher than estimated and IA probably contributes to many deaths. Improved rapid diagnosis of IA using culture and non-culture based techniques is required in COPD hospital admissions to reduce mortality

Feline emphysematous gastritis in a cat with pancreatitis and secondary hepatic lipidosis

A 7 yr old female neutered domestic shorthair was presented with a 2 mo history of lethargy and hyporexia progressing to anorexia. Initial diagnostics indicated pancreatitis with secondary hepatic lipidosis. Supportive care, including the placement of an esophageal feeding tube, was initiated. The feeding tube was removed traumatically by the cat and thus replaced. The cat acutely deteriorated while hospitalized, developing marked hypersalivation and an obtunded mentation. Radiographs were taken to confirm placement of the feeding tube in case tube dislodgement was contributing to the hypersalivation; results confirmed appropriate positioning and gastric pneumatosis. Despite intensified medical management, the patient suffered cardiopulmonary arrest 7 days after hospital admission. Post-mortem examination confirmed necrotizing gastritis with emphysema alongside segmental mucosal necrosis in the jejunum, focal pancreatic necrosis, and diffuse hepatic lipidosis. Gas in the gastric wall is a rare finding in veterinary medicine and can arise due to gastric pneumatosis or emphysematous gastritis; there are scant reports of either in feline medicine. This report documents a case of emphysematous gastritis in a cat with concurrent pancreatitis and hepatic lipidosis. The cat developed emphysematous gastritis without undergoing gastrointestinal surgery which is currently the only reported feline predis-posing factor for development

Influence of Precipitation and Crop Germination on Resource Selection by Mule Deer (\u3ci\u3eOdocoileus hemionus\u3c/i\u3e) in Southwest Colorado

Mule deer (Odocoileus hemionus) populations in the western United States provide many benefits to local economies but can also cause considerable damage to agriculture, particularly damage to lucrative crops. Limited information exists to understand resource selection of mule deer in response to annual variation in crop rotation and climatic conditions. We tested the hypothesis that mule deer select certain crops, and in particular sunflower, based on annual climatic variability. Our objective was to use movements, estimates of home range, and resource selection analysis to identify resources selected by mule deer. We used annually-derived crop-specific datasets along with Global Positioning System collars to monitor 14 mule deer in an agricultural area near public lands in southwestern Colorado, USA. We estimated home ranges for two winter seasons that ranged between 7.68 and 9.88 km2, and for two summer seasons that ranged between 5.51 and 6.24 km2. Mule deer selected areas closer to forest and alfalfa for most periods during 2012, but selected areas closer to sunflower in a majority of periods during 2013. Considerable annual variation in climate patterns and precipitation levels appeared to influence selection by mule deer because of variability in crop rotation and success of germination of specific crops

CAMEMBERT: A Mini-Neptunes GCM Intercomparison, Protocol Version 1.0. A CUISINES Model Intercomparison Project

With an increased focus on the observing and modelling of mini-Neptunes, there comes a need to better understand the tools we use to model their atmospheres. In this paper, we present the protocol for the CAMEMBERT (Comparing Atmospheric Models of Extrasolar Mini-neptunes Building and Envisioning Retrievals and Transits) project, an intercomparison of general circulation models (GCMs) used by the exoplanetary science community to simulate the atmospheres of mini-Neptunes. We focus on two targets well studied both observationally and theoretically with planned JWST Cycle 1 observations: the warm GJ~1214b and the cooler K2-18b. For each target, we consider a temperature-forced case, a clear sky dual-grey radiative transfer case, and a clear sky multi band radiative transfer case, covering a range of complexities and configurations where we know differences exist between GCMs in the literature. This paper presents all the details necessary to participate in the intercomparison, with the intention of presenting the results in future papers. Currently, there are eight GCMs participating (ExoCAM, Exo-FMS, FMS PCM, Generic PCM, MITgcm, RM-GCM, THOR, and the UM), and membership in the project remains open. Those interested in participating are invited to contact the authors.Comment: Accepted to PS

Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice

The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a neuromuscular disorder also characterized by intrinsic muscle pathologies, metabolic abnormalities and disrupted sleep patterns, which can influence or be influenced by circadian regulatory networks that control behavioral and metabolic rhythms. We therefore set out to investigate the contribution of the GC-KLF15-BCAA pathway in SMA pathophysiology of Taiwanese Smn−/−;SMN2 and Smn2B/− mouse models. We thus uncover substantial dysregulation of GC-KLF15-BCAA diurnal rhythmicity in serum, skeletal muscle and metabolic tissues of SMA mice. Importantly, modulating the components of the GC-KLF15-BCAA pathway via pharmacological (prednisolone), genetic (muscle-specific Klf15 overexpression) and dietary (BCAA supplementation) interventions significantly improves disease phenotypes in SMA mice. Our study highlights the GC-KLF15-BCAA pathway as a contributor to SMA pathogenesis and provides several treatment avenues to alleviate peripheral manifestations of the disease. The therapeutic potential of targeting metabolic perturbations by diet and commercially available drugs could have a broader implementation across other neuromuscular and metabolic disorders characterized by altered GC-KLF15-BCAA signaling

A systematic review of the effectiveness of antimicrobial rinse-free hand sanitizers for prevention of illness-related absenteeism in elementary school children

BACKGROUND: Absenteeism due to communicable illness is a major problem encountered by North American elementary school children. Although handwashing is a proven infection control measure, barriers exist in the school environment, which hinder compliance to this routine. Currently, alternative hand hygiene techniques are being considered, and one such technique is the use of antimicrobial rinse-free hand sanitizers. METHODS: A systematic review was conducted to examine the effectiveness of antimicrobial rinse-free hand sanitizer interventions in the elementary school setting. MEDLINE, EMBASE, Biological Abstract, CINAHL, HealthSTAR and Cochrane Controlled Trials Register were searched for both randomized and non-randomized controlled trials. Absenteeism due to communicable illness was the primary outcome variable. RESULTS: Six eligible studies, two of which were randomized, were identified (5 published studies, 1 published abstract). The quality of reporting was low. Due to a large amount of heterogeneity and low quality of reporting, no pooled estimates were calculated. There was a significant difference reported in favor of the intervention in all 5 published studies. CONCLUSIONS: The available evidence for the effectiveness of antimicrobial rinse-free hand sanitizer in the school environment is of low quality. The results suggest that the strength of the benefit should be interpreted with caution. Given the potential to reduce student absenteeism, teacher absenteeism, school operating costs, healthcare costs and parental absenteeism, a well-designed and analyzed trial is needed to optimize this hand hygiene technique